OUCH...was the first thing that came to mind in today's messed up world. Both effective calibers, but best wishes finding ammo or components without a lot of digging, searching or paying out the whazoo for what you can find. I'd take a .44 over the .41 if I was itching to own one. Shot quite a few rounds through other guys .44 S&W and Ruger revolvers. Even the 4" Shooter has listed can be managed with one hand by a fella with big mitts. Firing a hand cannon is something I don't care doing very often, but more punch with the heavier/bigger round in .44. I'll stick to the .357 and 45ACP as "big enough" to do what ever job I might need to use one.
Best wishes on reaching your own decision and good luck finding a ready and affordable supply of stuff to feed it whether revolver, carbine or even a rifle.