The Mil .5.56 brass, like all other DOD brass is thicker and beefer to handle the stronger loads. Make good reloading if you want to go thru the pocket reaming, ect.
Sierra does list the X-terminatior and TAC powder as AR-15 propellent. They have seperate data for ARs and Bolt guns. Sierra reccomends X-terminatior with a 50 gr. for hunting. The X-terminatior seems to produce higher velocities than the TAC. Of course with the sorter AR barrels Bolt gun speeds are not reached, load for load. Test gun for them was a Colt Match AR with a 1:7" twist barrel (20")
They list H335 with the best accuracy in the AR an Bolt guns. Listed for my gun I can get 3800 fps with a 40 gr bullet. Their data was with a 24" barrel 1:14" twist out of a Rem 600. My 26" should do a little better with the same twist.
As for the saftey margins in the data, when I talked to them about .38 data they were insistant (overly so) that they DO NOT publish +P data for the .38 or any other caliber.